Frontline Plus Cat Flea & Tick Treatment x1

Kills Fleas, Ticks & Lice*
*Kills biting lice on your cat.

Indication(s)
In cats:
To be used against infestations with fleas, alone or in association with ticks and/or biting lice.
- Treatment of flea infestations (Ctenocephalides spp.). Insecticidal efficacy against new infestations with adult fleas persists for 4 weeks. Prevention of the multiplication of fleas by inhibiting the development of eggs (ovicidal activity), larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas for six weeks after application.
- Treatment of tick infestations (Ixodes ricinus, Dermacentor variabilis, Rhipicephalus sanguineus). The product has a persistent acaricidal efficacy for up to 2 weeks against ticks (based on experimental data).
- Treatment of infestations with biting lice (Felicola subrostratus).

In ferrets:
To be used against infestations with fleas, alone or in association with ticks.
- Treatment of flea infestations (Ctenocephalides spp.). Insecticidal efficacy against new infestations with adult fleas persists for 4 weeks. Prevention of the multiplication of fleas by inhibiting the development of eggs (ovicidal activity), larvae and pupae (larvicidal activity) originating from eggs laid by adult fleas.
- Treatment of tick infestations (Ixodes ricinus). The product has a persistent acaricidal efficacy for 4 weeks against ticks (based on experimental data).

Target Species: Cat, Ferret

1 pipette of 0.5 ml
Fipronil 10% w/v + [S]-methoprene 12% w/v

Special Precautions for the Disposal of Unused Product or Waste Material
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.
Fipronil and (S)-methoprene may adversely affect aquatic organisms. Do not contaminate ponds, waterways or ditches with the product or empty containers

Pharmacodynamic properties
Fipronil kills fleas within 24 hours and ticks and lice within 48 hours post-exposure.
Blister card of 1x 0.5 ml pipette
Box of 1 blister card of 3 x 0.5 ml pipettes
Box of 1 blister card of 4 x 0.5 ml pipettes
Box of 2 blister cards of 3 x 0.5 ml pipettes
Not all pack sizes may be marketed.

Marketing Authorisation Holder:
Boehringer Ingelheim Animal Health UK Ltd,
Bracknell,
RG12 8YS,
UK.

Boehringer Ingelheim Animal Health France SCS,
4 Chemin du Calquet,
31000 Toulouse,
France.

Read the package leaflet for full instructions and for user and environmental precautions.

For animal treatment only.

Contraindications
In the absence of available data, the product should not be used on kittens less than 8 weeks old and/or weighing less than 1 kg. The product should not be used in ferrets less than 6 months old.
Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
Do not use in rabbits, as adverse drug reactions and even mortality could occur. In absence of studies, the use of the product is not recommended in non-target species.
Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
In the absence of safety studies, the minimum treatment interval is 4 weeks in cats and ferrets.

Adverse Reactions
Do not overdose.
Among the very rare suspected adverse reactions, transient skin reactions on the application site (scaling, local hairloss, itching, redness) and general itching or hair loss have been reported after use. Excessive salivation, reversible nervous signs (increased sensitivity to stimulation, depression, other nervous signs) or vomiting have also been observed after use.
If licking occurs, a brief period of excessive salivation may be observed due mainly to the nature of the carrier.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated reports).
If you notice any serious effects or other effects not mentioned here, please inform your veterinary surgeon.

Dosage for Each Species, Route(s) and Method of Administration

Route of administration:
External, by topical application to the skin.
Dosage:
One pipette of 0.5 ml per cat corresponding to a minimum recommended dose of 5 mg/kg for fipronil and 6 mg/kg for (S)-methoprene.
One pipette of 0.5 ml per ferret corresponding to a dose of 50 mg for fipronil and 60 mg for (S)-methoprene per ferret, by topical application to the skin.

Advice on Correct Administration
1 Take the pipette out of its packaging. Hold the pipette upright. Tap the narrow part of the pipette to ensure the contents remain within the main body of the pipette. Snap back the tip.
2 Part the coat on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible
3 Place the tip of the pipette on the skin and squeeze the pipette several times to empty its contents completely and directly onto the skin in one spot.

Use during pregnancy, lactation or lay
The product can be used during pregnancy in cats. Consult your veterinary surgeon before using the product in lactating queens, or in pregnant or lactating jills.

Keep out of the sight and reach of children.

SPECIAL WARNINGS(s)
Precautions
It is important to make sure that the product is applied to an area where the animal cannot lick it off and to make sure that animals do not lick each other following treatment.
When treating infestations of parasites, all in-contact animals should be treated with an appropriate product at the same time. Do not use simultaneously with other flea products which are applied directly on to the animal.
No data on the effect of bathing/shampooing on the efficacy of the product in cats and ferrets are available. However, based on information available for dogs shampooed from 2 days after application of the product, it is not recommended to bath animals within 2 days after application of the product.
Avoid contact with the animal's eyes.
There may be an attachment of single ticks. For this reason a transmission of infectious diseases cannot be completely excluded if conditions are unfavourable.
Fleas from pets often infest the animal's basket, bedding and regular resting areas such as carpets and soft furnishings which should be treated, in case of massive infestation and at the beginning of the control measures, with a suitable insecticide and vacuumed regularly.
The potential toxicity of the product for kittens of less than 8 weeks of age in contact with a treated queen is not documented. Special care should be taken in this case.
Animals should be weighed accurately prior to treatment.

User Warnings
Keep pipettes in original packaging until ready to use. In order to prevent children from getting access to used pipettes, dispose of used pipettes immediately.
This product can cause mucous membrane, skin and eye irritation. Therefore, contact of the product with mouth, skin and eyes should be avoided.
If the product is accidentally swallowed, seek medical advice immediately and show the package leaflet to the physician.
People with a known hypersensitivity (allergy) to insecticides or alcohol should avoid contact with the product.
Avoid contents coming into contact with the fingers. If this occurs, wash hands with soap and water.
After accidental exposure the eye should be rinsed carefully with pure water.
Wash hands after use.
Treated animals should not be handled until the application site is dry, and children should not be allowed to play with treated animals until the application site is dry. It is therefore recommended that animals are not treated during the day, but should be treated during the early evening, and that recently treated animals are not allowed to sleep with owners, especially children.
Do not smoke, drink or eat during application.

Other Precautions
The alcohol carrier may have adverse effects on painted, varnished or other household surfaces or furnishings.

Overdose
The risk of experiencing adverse effects may however increase with overdosing (see Undesirable Effects).

Cats
No undesirable effects were observed in target animal safety studies in cats and kittens aged 8 weeks and older and weighing about 1 kg treated once a month at five times the recommended dose for six consecutive months.
Itching may occur following treatment.
Overdose application of the product will cause a sticky appearance of hairs at the treatment spot. However, should this occur, it will disappear within 24 hours post application.

Ferrets
In ferrets aged 6 months and older and treated once every 2 weeks for four treatments, at five times the recommended dose, body weight loss was observed in some animals.

Do not store above 30°C. Store in the original package.
Do not use this veterinary medicinal product after the expiry date stated on the package after Exp.
The expiry date refers to the last day of the month.